Company Description
AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas immunology, oncology, neuroscience, and eye care and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at . on X , Facebook , Instagram , YouTube , LinkedIn and Tik Tok .
Job Description
Overview
The Development Sciences Biologics Drug Product Development organization within AbbVie develops and characterizes drug product formulations and manufacturing processes to provide clinical dosage forms to enable the development of AbbVies pipeline. AbbVie is seeking a highly motivated person to join the Biologics CMC Developability Team. The candidate will leverage mass spectrometry and other advanced characterization techniques to support the early-stage assessment of candidates coming out of the Discovery pipeline with the opportunity to influence the design and development of stable drug product formulation and manufacturing processes for biologics used in clinical trials. In addition, the candidate will be expected to drive key scientific initiatives and lead innovative approaches to improve current workflows. In this role, the candidate will be a member of a global team and will work closely with scientists from multiple functional areas, including Discovery, Analytical, Process R&D, and Product Development Science & Technology.
Key Responsibilities:
- Lead developability assessment activities, including candidate screening and selection for clinical studies of monoclonal antibodies, antibody drug conjugates, bispecifics, and fusion proteins.
- Employ modern LC-MS instruments to understand structural information insight of therapeutic biologic molecules to influence amino acid sequence design and selection.
- Develop independent research ideas and pursue scientific questions that may arise during developability studies. Presents data at internal and external professional conferences and prepares manuscripts for publication in peer reviewed journals or patent applications. Supports and contributes to ongoing independent research projects.
- Ability to build and manage strategic alignments with key stakeholders, revise and improve business workflows, manage project timelines and resources. Develops the optimal CMC development path for assigned discovery projects together with clients from various R&D functions with an emphasis on collaboration, quality and with a sense of urgency.
Qualifications
- PhD in Biochemistry with no required work experience, MS in Biochemistry with at least 8 years of relevant experience, or a BS in Biochemistry with a minimum of 10 years of relevant work experience.
- Ideally, candidates will also have at least 2 years of experience in the comprehensive characterization of monoclonal antibodies within an industrial setting.
- Deep understanding of protein characterization by LC/ESI-HR-MS (e.g., peptide Mapping, intact mass analysis)
- Additional robotics expertise and protein analytical experience (e.g., SEC, IEX, HIC, CE) is beneficial
- Knowledge of functional excipient degradation pathways is a plus
- Solid understanding of the scientific approaches to develop commercially viable protein drug products.
Key Competencies:
- Builds strong relationships with peers and cross functionally with partners outside of the team to enable higher performance.
- Excellent oral communication skills in a scientific setting as well as sound technical writing and documentation competencies are required.
- The candidate must be able to work independently, respond to changing priorities and short lead times for multiple tasks; able to identify problems and work toward solutions.
- Raises the bar and is never satisfied with the status quo.
- Creates a learning environment, open to suggestions and experimentation for improvement.
- Embraces the ideas of others, nurtures innovation and manages innovation to reality.
Additional Information
Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:
- This is an on-site opportunity located in AbbVie's campus north of Chicago, IL.
- The compensation range described below is the range of possible base pay compensation that the Company believes ingood faith it will pay for this role at the time of this posting based on the job grade for this position. Individualcompensation paid within this range will depend on many factors including geographic location, and we may ultimatelypay more or less than the posted range. This range may be modified in the future.
- We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/visioninsurance and 401(k) to eligible employees.
- This job is eligible to participate in our short-term incentive programs.
Note: No amount of payis considered to bewages or compensation until such amount is earned, vested, and determinable.The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefitsthat are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid andmay be modified at the Companys sole and absolute discretion, consistent with applicable law.
AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion. It is AbbVies policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.
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