Scientist

HOW MIGHT YOU DEFY IMAGINATION?

Youve worked hard to become the professional you are today and are now ready to take the next step in your career. How will you put your skills, experience and passion to work toward your goals? At Amgen, our shared missionto serve patientsdrives all that we do. It is key to our becoming one of the worlds leading biotechnology companies, reaching over 10 million patients worldwide. Come do your best work alongside other innovative, driven professionals in this meaningful role.

Scientist - Biochemistry & Pharmacology

What you will do

Lets do this. Lets change the world. Amgen is seeking a talented and motivated individual with expertise in biochemical & cell-based assay development in support of Amgens small molecule drug discovery pipeline. In this vital role you will be responsible for designing, developing, and optimizing assays to identify and validate potential drug candidates, including reversible inhibitors, covalent inhibitors, and degraders. The successful candidate should possess strong technical expertise & laboratory skills, have excellent written and oral communication skills, work productively in a collaborative cross-functional team environment, and keep current with field of expertise, including literature and technology development

• Develop and optimize biochemical assays to support HTS, hits validation, and lead optimization for novel therapeutic targets

• Develop and execute cell-based assays to assess the effects of small molecules on cellular pathways, receptor activity, and phenotypic outcomes

• Apply sophisticated bioassay techniques to develop and perform potency, kinetic and mechanistic assays for hits validation, compound-target engagement, and SAR study

• Evaluate and implement new technologies to enhance screen capabilities and assay performance

• Stay current with scientific literature and industry trends related to assay technologies, novel drug modalities, and drug discovery

• Represent department in multi-disciplinary project teams to present research results and provide scientific and technical support

• Collaborate with internal cross-functional teams and external partners to enable project progression

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The professional we seek is a motivated scientist with these qualifications.

Doctorate & relevant scientific experience

Masters degree & 2 years of scientific experience

• PhD in Biochemistry, Pharmacology, Cell Biology, Molecular Biology or a related field, with relevant postdoctoral experience preferred

• Expertise in quantitative pharmacology, enzymology, and ligand binding kinetics.

• Small molecule drug discovery experience in novel modalities including but not limited to reversible inhibitors, covalent inhibitors, or degraders.

• A deep and broad understanding of the development, validation & execution of a wide array of binding & functional activity-based assays such as AlphaScreen, TR-FRET, FP, etc.

• Demonstrated ability to develop and implement cellular assays for target validation, hit identification, and lead optimization, such as MesoScale Discovery, HiBIT, NanoBRET, and cell reporter assays

• Highly skilled in the development & implementation of robust, automated, 384 or 1536-well plate-based assays using a wide range of detection methods (e.g., spectrophotometry, radiometry, luminescence, fluorescence)

• Experience with microplate readers and automated liquid handling systems (e.g., PerkinElmer Envision, Labcyte Echo, Agilent Bravo, etc.)

• Experience with data analysis and visualization software platforms (e.g., Genedata Screener, Tibco Spotfire, GraphPad Prism, etc.)

• Excellent organizational, interpersonal and communication skills, along with the ability to work in a flexible team-oriented environment

What you can expect of us

As we work to develop treatments that take care of others, we also work to care for our teammates professional and personal growth and well-being.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

Amgen offers a Total Rewards Plan comprising health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities including:

• Comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts.

• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan

• Stock-based long-term incentives

• Award-winning time-off plans and bi-annual company-wide shutdowns

• Flexible work models, including remote work arrangements, where possible

for a career that defies imagination

Objects in your future are closer than they appear. Join us.

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.