At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.
The Lilly Small Molecule Discovery group is an organization purpose-built to create molecules that make life better for people. We focus on using cutting edge science to unlock new approaches that can treat people suffering from diseases with poor treatment options. We continually challenge ourselves to deliver molecules that can provide breakthrough efficacy with the highest possible safety margins. We are dedicated to optimizing our mindset, technology, and processes for faster, more nimble execution. Our success is built on a culture that empowers innovative problem solving through open collaboration and individual accountability.
Position Summary:
Lilly's newly created Early Molecule Discovery team is responsible for small molecule hit to lead prosecution using traditional, and where warranted, novel mechanisms and technologies on early pre-portfolio targets. Our group is looking for 1-2 experienced drug hunters as the Director of Mechanistic Biochemistry, who is responsible for leading the team tasked with developing biochemical assays that facilitate the screening and characterization of novel inhibitors or binders, often in the tough to drug space. As well as rapidly, and rigorously, define the mechanism of action of hit compounds towards targets and anti-targets of interest. Helping our teams focus on those compounds that best align with the target product profile. In this position, the candidate will direct efforts across multiple programs, in parallel, including driving the evaluation and development of novel assay technologies and platforms, both internally and externally.
Responsibilities:
"Lead from the bench" by actively participating in the team's research activities (i.e. hands-on experimental work, experimental design, advanced analysis, etc.)
Technically proficient in methods to measure biochemical activities of proteins, including but not limited to HTRF, Alphalisa, FP, ligand displacement, luminescence, MS, UV-Vis, and Absorbance.
Basic Requirements:
Additional Preferences:
Highly organized with excellent analytical, documentation, time management, and multi-tasking skills.
Additional Information:
Physical Demands/Travel:
The physical demands of this job are consistent with a lab environment.
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
This position will require some travel 5-10% of the time
Work Environment:
This position's work environment is in a Laboratory.
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.
Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.
Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women's Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.
Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is
$156,000 - $250,800
Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.