Staff Research Scientist

The Akassoglou Lab at The Gladstone Institutes is seeking a highly skilled imaging-oriented engineer to join our group as a Staff Research Scientist-Imaging Engineer. The mission of the position is to develop technologies to investigate the interactions between the immune, vascular and nervous systems with the aim to understand dynamic biological processes and decipher the sequence of events and their causative relationship that lead to disease and utilize these tools to design and test effective treatments. For recent publication on microglia in brain network hyperexcitability see Merlini et al., Nat Neurosci Nat Neurosci 24,19-23 (2021) . The person in the position will be responsible for the following:

• Plan, design, initiate, interpret and report experiments using repetitive two-photon imaging and confocal microscopy in the living mouse brain and spinal cord

• Lead the development and implementation of new technologies and protocols for advanced in two-photon imaging applications (e.g. functional imaging, labeling methods)

• Develop new projects and support ongoing research projects

• Establish in-house expertise in animal models reporters relevant to intravital imaging

• Project management of research collaborations, including technical training of new personnel, supervision of two-photon microscopy experiments, administrative tasks

• Assist with processing, analysis and interpretation of imaging data

• Develop code/scripts for image analysis and acquisition pipeline

• Screen and test novel imaging-based instrumentation

• Develop grant applications for purchase of new equipment, personnel support, and collaborative grant applications

• Day-to-day maintenance of imaging set-ups, including laser equipment

• Work and communicate effectively with collaborators, as well as administrative departments and IT

• Ensure compliance with relevant regulatory guideline with EH/S and IACUC

Qualifications

• PhD in Bioengineering, Physics, Neurobiology, Physiology, Immunology or related fields with at least 3 years postdoctoral experience in a biomedical and/or research and development environment

• At least 2 years of in vivo imaging experience

• In depth knowledge of optics, fluorescence microscopy, and live imaging of biological material. Rodent handling and surgical experience essential.

• Expertise in developing and implementing new imaging modalities and customized software tools for 4D image data analysis (Image J, FluoView, Imaris, Volocity).

• Computational skills in bioinformatics are required (R, MATLAB, Python)

• Strong research interest in neuroimmunology, neurodegeneration, and cell biology

Preferred skills:

• Experience with genomics

Hiring range (DOE):

$93K - $150K

• Title and salary will be commensurate with education and experience.
• Gladstone is an equal opportunity employer.