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4DMT is a clinical-stage biotherapeutics company harnessing the power of directed evolution for targeted genetic medicines. We seek to unlock the full potential of gene therapy using our platform, Therapeutic Vector Evolution (TVE), which combines the power of directed evolution with our approximately one billion synthetic AAV capsid-derived sequences to invent evolved vectors for use in our products. We believe key features of our targeted and evolved vectors will help us create targeted product candidates with improved therapeutic profiles. These profiles will allow us to treat a broad range of large market diseases, unlike most current genetic medicines that generally focus on rare or small market diseases.
We have built a deep portfolio of AVV-based gene therapy product candidates, with five product candidates in clinical trials: 4D-150 for the treatment of wet age-related macular degeneration (wet AMD) and diabetic macular edema (DME), 4D-710 for the treatment of cystic fibrosis lung disease, 4D-310 for the treatment of Fabry disease cardiomyopathy, 4D-125 for the treatment of X-linked retinitis pigmentosa (XLRP), and 4D-110 for the treatment of choroideremia. In addition, we have two product candidates in preclinical studies: 4D-175 for geographic atrophy (GA) and 4D-725 for alpha-1 antitrypsin deficiency.
To-date, we have demonstrated clinical proof-of-concept for three evolved vectors in three therapeutic areas and routes of administration with five products and patient populations. We believe this validates the power of our directed evolution platform for discovering superior vectors compared to wildtype viral vectors. We have built a robust and efficient product engine with 6 open Investigational New Drug Applications (INDs) in the U.S., 1 IND in Taiwan, and 1 Clinical Trial Approval (CTA) in Australia. We believe we are positioned to create, develop, manufacture and, if approved, effectively commercialize targeted genetic medicines that could transform the lives of patients suffering from debilitating diseases.
In addition to TVE, our technology includes a robust AAV manufacturing platform and onsite manufacturing facility that allows us to rapidly produce and test research grade material and scale up to GMP clinical material. This internal capability and close collaboration between our R&D and Manufacturing teams has greatly accelerated the pace of discovery at 4DMT.
Company Differentiators:
• Fully integrated clinical-phase company with internal manufacturing
• Demonstrated ability to move rapidly from idea to IND
• Five candidate products in the clinic and two declared pre-clinical programs
• Robust technology and IP foundation, including our TVE and manufacturing platforms
• Initial product safety and efficacy data substantiates the value of our platforms
• Opportunities to expand to other indications and modalities within genetic medicine
GENERAL SUMMARY:
4D Molecular Therapeutics (4DMT) is a rapidly growing biotherapeutics company focused on developing and commercializing targeted genetics medicines using its gene therapy platform, Therapeutic Vector Evolution (TVE), with lead product candidates in the areas of ophthalmology and pulmonology. Accordingly, 4DMT is seeking a Senior Paralegal to provide transactional support for the late-stage clinical programs as well as corporate support for standard public filings. Reporting to the Senior Director, Corporate Counsel, this person will draft and negotiate standard contracts, including CTAs, MSAs, CDAs, SOWs, change orders, consulting agreements, and amendments; and support filings, record keeping, and other administrative work related to SEC, SOX, GDPR, and other compliance regimes. The ideal candidate will have strong experience in these areas to work independently and in a fast-paced environment, with specific experience in the biotechnology / pharmaceutical industry. This position is hybrid with corporate headquarters in Emeryville, CA.
RESPONSIBILITIES:
- Drafts, reviews, negotiates, and manages a variety of transactional agreements and amendments, including clinical trial agreements, master services agreements, consulting agreements, statements of work, and non-disclosure agreements, with minimal attorney supervision.
- Assists attorneys with the creation of contract templates, playbooks, and client training; assists and/or manages special projects and enterprise-wide initiatives as needed.
- Assists with certain SEC filings, including Form 3 / 4 filings.
- Proactively identifies, performs analyses, proposes solutions, and provides guidance directly to business clients.
- Works with Legal Operations to support 4DMT's contract management system.
- Other duties as assigned, nothing in this job description restricts management's right to assign or reassign duties and responsibilities to this job at any time
QUALIFICATIONS:
Education:
- Bachelor's degrees and/or relevant legal education (paralegal certification)
Experience:
- Minimum 8 years of paralegal experience in a law firm or in-house law department at a public biotechnology / pharmaceutical company
Skills:
- Excellent communication (verbal and written), listening and negotiation skills
- Experience with contract management systems (Ironclad a plus)
- Ability to engage critical thinking in order to provide a solutions-oriented approach to client needs.
- A strong self-starter who is adaptable, flexible, and creative in a rapidly changing environment
- Can manage several complex projects simultaneously while working to meet deadlines; includes planning and prioritizing work without direct supervision
- A history of operating with transparency, professionalism, emotional intelligence, and integrity.
Base salary compensation range:
Bay Area Range: $133,000/yr - $150,000/yr
Please note that the base salary compensation range and actual salary offered to the final candidate depends on various factors: the candidate's geographical location, relevant work experience, skills, and years of experience.
4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities