OPPORTUNITY
Mammoth's Editing Technologies team is hiring a Sr. Scientist I/II to play a lead role in the development of a next-generation genome editing platform. The successful candidate will optimize the platform technology for efficacy and specificity in mammalian cells to enable in vivo editing of various therapeutic targets. The role will emphasize protein engineering, gRNA screening and NGS assays in mammalian cell lines. This is a fantastic opportunity to impact human health by making CRISPR tools that cure genetic disease.
KEY RESPONSIBILITIES- Plan, design and execute experiments for CRISPR tool development projects
- Design and produce DNA and RNA-based reagents for genome editing experiments in human cells
- Contribute creatively to seed innovation projects through literature review and shape execution tactics
- Provide instruction to junior team members
- Document experiments in electronic laboratory notebooks
- Present experimental results at internal meetings
- Disclose inventions to the IP team for patenting
- Other duties as assigned
REQUIRED QUALIFICATIONS- PhD in Molecular Biology, Biochemistry, Biomolecular Engineering or a related discipline; +3 years of relevant professional experience in industry or academia, following completion of PhD
- Experience using protein engineering approaches to develop novel CRISPR tools for gene editing in mammalian cells
- Experience with NGS assays and readout for gene editing
PREFERRED QUALIFICATIONS- Experience with base editors or prime editors
- Experience with structure-guided or homology-guided design approaches for protein engineering
- Experience designing and implementing directed evolution approaches for gene editing improvements
- Experience managing junior staff
- Experience working with flow cytometry
- Working proficiency with common bioinformatics tools (Benchling, JMP, SQL, R, Python)
BENEFITS- Company-paid health/vision/dental benefits
- Unlimited vacation and generous sick time
- Company-sponsored meals and snacks
- Wellness, caregiver and ergonomics, mental health and education benefits
- 401(k) with company matching
Base Salary Range: $ 155,000 - $182,350
The listed base salary range is for Mammoth employees in the Bay Area. Actual base salary will be determined by geographic work location, relevant professional experience, applicable skills, and internal equity. The base salary range for those working remotely outside of the San Francisco Bay Area may differ and will be determined by industry market data for the role and specific region.
Mammoth Biosciences is a biotechnology company focused on leveraging its proprietary ultracompact CRISPR systems to develop long-term curative therapies, as well as other applications such as decentralized precision diagnostics. Founded by CRISPR pioneer and Nobel laureate Jennifer Doudna and Trevor Martin, Janice Chen, and Lucas Harrington, the company's ultracompact proteins are designed to enable in vivo gene editing in difficult to reach tissues utilizing both nuclease applications and new editing modalities beyond double stranded breaks, including base editing, gene writing, and epigenetic editing. The company is building out its pipeline of potential in vivo gene editing therapeutics and capabilities and has partnerships with leading pharmaceutical and biotechnology companies to broaden the reach of its innovative and proprietary technology. Mammoth's deep science and industry experience, along with a robust and differentiated intellectual property portfolio, have enabled the company to further its mission to transform the lives of patients and deliver on the full promise of CRISPR technologies.
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