Posted 30+ Days Ago
Discover Vanderbilt University Medical Center: Located in Nashville, Tennessee, and operating at a global crossroads of teaching, discovery, and patient care, VUMC is a community of diverse individuals who come to work each day with the simple aim of changing the world. It is a place where your expertise will be valued, your knowledge expanded, and your abilities challenged. Vanderbilt Health recognizes that diversity is essential for excellence and innovation. We are committed to an inclusive environment where everyone has the chance to thrive and where your diversity of culture, thinking, learning, and leading is sought and celebrated. It is a place where employees know they are part of something that is bigger than themselves, take exceptional pride in their work and never settle for what was good enough yesterday. Vanderbilt's mission is to advance health and wellness through preeminent programs in patient care, education, and research.
Organization:OTO AE - Admin
Job Summary:JOB SUMMARY
Our lab is looking for a dedicated position with expertise in protein chemistry, GLP/GMP manufacturing, antibody chemistry/labeling, and/or HPLC techniques to directly assist with cGMP production and formulation of radio- or optically labeled antibodies for use in clinical trials at Vanderbilt University Medical Center. Our research aims to combine nuclear medicine oprical labeled probes for precision surgery utilizing cancer-targeted moieties (antibodies, affibodies, small molecules, etc.) conjugated to radioisotopes (89Zr, 111In, 18F, 68Ga, etc.) or optical labels (IRDye800, ICG). We are actively seeking a research-minded antibody chemist who wants to contribute to our research program by development of new probes through the optimization and addition of novel conjugations methodologies to not only improve detection, but also overcome gaps in clinical care that exist with current nuclear medicine approaches. We propose to develop novel imaging agents.
In addition to radioisotope production, our lab investigates optically labeled agents for fluorescent-guided surgery. We are pursuing a novel cGMP production strategy for these optical agents within the radiochemistry core, and seek a motivated and curious radiochemist to develop this groundbreaking methodology. A background in molecular biology and/or protein biology is desirable but not a prerequisite.
This position will work directly with one principal investigator, who has nearly a decade of experience in molecular-guided surgery and is at the forefront of innovations within the field. Anyone with a strong background in radiochemistry and motivated in clinical research is encouraged to apply.
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KEY RESPONSIBILITIES
- Perform labeling of antibodies production in a benchtop, fume hood, glove box, or hot cell environments under GMP conditions
- Conduct research and development activities with the goal of identifying new labeling strategies, increasing efficiency, or identifying novel applications
- Development of an optically-labeled platform under GMP conditions using radioisotope productions as a framework
- Work with a team of radiochemists, surgeons, and scientists to investigate novel and clinically-relevant questions
- Publish results in peer reviewed journals
Qualifications:
- PhD in radiochemistry, chemistry, chemical engineering, or similar field with minimum two years' experience or Bachelor's/Master's in similar field with minimum five years' experience with antibody chemistry/radiochemical production
- Understanding of GMP regulation, documentation, and testing for radiolabeled products
- Ability to operate and troubleshoot HPLC-SEC, GC-MS, LS-MS
- Ability to multi-task and execute in a timely manner to ensure product availability for clinical use
- Establish and maintain good rapport with other radiochemists, surgeons, scientists, and clinical coordinators
- Desire to interrogate new questions and eager to try new methodologies
TECHNICAL CAPABILITIES
Our professional administrative functions include critical supporting roles in information technology and informatics, finance, administration, legal and community affairs, human resources, communications and marketing, development, facilities, and many more.
At our growing health system, we support each other and encourage excellence among all who are part of our workforce. High-achieving employees stay at Vanderbilt Health for professional growth, appreciation of benefits, and a sense of community and purpose.
Core Accountabilities:Organizational Impact: Independently delivers on objectives with understanding of how they impact the results of own area/team and other related teams. Problem Solving/ Complexity of work: Utilizes multiple sources of data to analyze and resolve complex problems; may take a new perspective on existing solution. Breadth of Knowledge: Has advanced knowledge within a professional area and basic knowledge across related areas. Team Interaction: Acts as a "go-to" resource for colleagues with less experience; may lead small project teams.
Core Capabilities : Supporting Colleagues: - Develops Self and Others: Invests time, energy, and enthusiasm in developing self/others to help improve performance e and gain knowledge in new areas. - Builds and Maintains Relationships: Maintains regular contact with key colleagues and stakeholders using formal and informal opportunities to expand and strengthen relationships. - Communicates Effectively: Recognizes group interactions and modifies one's own communication style to suit different situations and audiences. Delivering Excellent Services: - Serves Others with Compassion: Seeks to understand current and future needs of relevant stakeholders and customizes services to better address them. - Solves Complex Problems: Approaches problems from different angles; Identifies new possibilities to interpret opportunities and develop concrete solutions. - Offers Meaningful Advice and Support: Provides ongoing support and coaching in a constructive manner to increase employees' effectiveness. Ensuring High Quality: - Performs Excellent Work: Engages regularly in formal and informal dialogue about quality; directly addresses quality issues promptly. - Ensures Continuous Improvement: Applies various learning experiences by looking beyond symptoms to uncover underlying causes of problems and identifies ways to resolve them. - Fulfills Safety and Regulatory Requirements: Understands all aspects of providing a safe environment and performs routine safety checks to prevent safety hazards from occurring. Managing Resources Effectively: - Demonstrates Accountability: Demonstrates a sense of ownership, focusing on and driving critical issues to closure. - Stewards Organizational Resources: Applies understanding of the departmental work to effectively manage resources for a department/area. - Makes Data Driven Decisions: Demonstrates strong understanding of the information or data to identify and elevate opportunities. Fostering Innovation: - Generates New Ideas: Proactively identifies new ideas/opportunities from multiple sources or methods to improve processes beyond conventional approaches. - Applies Technology: Demonstrates an enthusiasm for learning new technologies, tools, and procedures to address short-term challenges. - Adapts to Change: Views difficult situations and/or problems as opportunities for improvement; actively embraces change instead of emphasizing negative elements.
Position Qualifications: Responsibilities: Certifications: Work Experience: Relevant Work Experience
Experience Level:5 years
Education: Doctorate
Vanderbilt Health recognizes that diversity is essential for excellence and innovation. We are committed to an inclusive environment where everyone has the chance to thrive and to the principles of equal opportunity and affirmative action. EOE/AA/Women/Minority/Vets/Disabled
Discover Vanderbilt Health:Located in Nashville, TN, and operating at a global crossroads of teaching, discovery and patient care, Vanderbilt Health is a community of individuals who come to work each day with the simple aim of changing the world. It is a place where your expertise will be valued, your knowledge expanded, and your abilities challenged. It is a place where diversity of culture, thinking, learning and leading is sought and celebrated. It is a place where employees know they are part of something that is bigger than themselves, take exceptional pride in their work and never settle for what was good enough yesterday.
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