Process Development Engineer III

Regeneron's Preclinical Manufacturing and Process Development (PMPD) group is looking for a highly motivated Process Development Engineer III: Upstream Development Gene Therapy, responsible for upstream development efforts to support manufacturing process development functions. In this role, you will work as part of a multi-functional team to provide Adeno-Associated Virus (AAV) manufacturing processes and products with the aim of providing treatment to unmet medical needs through gene therapy. This is a growth opportunity that combines the excitement and opportunity of a start-up with the security and institution knowledge gained from working for a larger firm.

A Typical Day in the Role of Process Development Engineer III Might Look Like:

• Design optimized, characterized and robust seed train and bioreactor processes for the upstream production of viral vectors in suspension cell lines suitable for future GMP clinical production.
• Lead the design and execution of studies for the optimization of transfection and bioreactor parameters for viral production using multivariate design of experiment approaches.
• Serve as upstream subject matter expertise and lead technology transfer to clinical manufacturing for future gene therapy programs.
• Support in-house viral vector producer cell line development and process optimization
• Contribute to optimization studies for the development of in-house chemically defined medium for viral production through design of experiment approach and omics analysis.
• Conduct technology development studies aimed at enhancing the understanding of or improving viral production process.
• Cross-train on and provide support for analytical and downstream operations.

• Have solid experience with mammalian cell culture; HEK cell culture experience is a plus; experience with JMP is preferred.
• You have strong initiative and drive to complete challenging tasks and learn new technologies.
• You are capable of multi-tasking, working both independently and within a team environment.
• You have the ability to design experiments, statistically interpret results, and communicate findings.
• You are motivated, have excellent verbal and written communication skills, and record-keeping abilities with a strong sense of accuracy to analyze and document development data generated

This position requires a Ph.D. degree with 0-2 years of experience and/or Masters degree with 5-7 years of experience in either Chemical Engineering, Biochemical Engineering, Biochemistry, or related field. The extent of the candidates prior experience will determine the grade of the position. A history of developing upstream steps within bioprocesses and experience with bioreactor scale up and operations is preferred. Proven experience with some of the following systems is preferred: NOVA FLEX, AMBR250 bioreactors, Bench top bioreactors, Single-use bioreactors (50-500 L), Biosafety cabinets, incubators, autoclave, Rockwell RSView32, Pi Historian, JMP, LIMS. Prior experience with producing AAV-based gene therapies is a plus. Job will periodically require short duration physical exertions, including light-medium weight lifting.

Does this sound like you? Apply now to take your first step towards living the Regeneron Way. We have an inclusive and diverse culture that provides comprehensive benefits, which often include (depending on location) health and wellness programs, fitness centers, equity awards, annual bonuses, and paid time off for eligible employees at all levels.

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. The Company will also provide reasonable accommodation to the known disabilities or chronic illnesses of an otherwise qualified applicant for employment, unless the accommodation would impose undue hardship on the operation of the Company's business.

For roles in which the hired candidate will be working in the U.S., the salary ranges provided are shown in accordance with U.S. law and apply to U.S.-based positions. For roles which will be based in Japan and/or Canada, the salary ranges are shown in accordance with the applicable local law and currency. If you are outside the U.S, Japan or Canada, please speak with your recruiter about salaries and benefits in your location.

Please note that certain background checks will form part of the recruitment process. Background checks will be conducted in accordance with the law of the country where the position is based, including the type of background checks conducted. The purpose of carrying out such checks is for Regeneron to verify certain information regarding a candidate prior to the commencement of employment such as identity, right to work, educational qualifications etc.

Salary Range (annually)