Job Description - Bioinformaticist (Rossin and Zebardast)
Job Description
Bioinformaticist (Rossin and Zebardast) - ( )
Description
We are seeking a highly qualified and motivated Bioinformaticist or computational biologist to join our collaborative teams in the Ocular Genomics Institute and the Department of Ophthalmology at Massachusetts Eye and Ear (MEE), Harvard Medical School, to work on innovative projects that combine human genetics and functional genomics to uncover novel causal mechanisms for glaucoma, a leading cause of irreversible blindness worldwide .
The successful candidate should have a MSc or PhD in bioinformatics, computational biology, biostatistics, computer science, or a related quantitative field, and will be interested to apply and develop computational and statistical methods for analyzing sequencing data, large-scale genotype-phenotype association studies, and functional genomics data. The ideal candidate will have strong programming skills, a solid statistical understanding, and experience with large-scale data analysis, ideally with genomic or other omic data, and will be excited to contribute to advancing the scientific discovery and medicine of eye disease.
The candidate will work with Drs Segre and Zebardast , that are part of a vibrant research community of computational biologists, experimentalists and clinician scientists in the Ocular Genomics Institute at MEE, an international leader for treatment and research in Ophthalmology and Otolaryngology. The labs are affiliated with the Medical and Population Genetics community a t the Broad Institute of Harvard and MIT. Being a member of our group will provide the opportunity to contribute to impactful projects and large collaborative efforts in the field of genomics and human disease. To learn more about our lab research directions please visit:
If interested, please send your CV, a cover letter describing your previous research experience and future research interests, and contact information for 3 references, to Dr. Nazlee Zebardasrt : Nazlee Zebardast at meei.harvard.edu and Dr. Lizzy Rossin: Elizabeth Rossin at meei.harvard.edu.
CHARACTERISTIC DUTIES: - Perform preprocessing and quality control of genotype array, whole exome and whole genome sequencing data, using existing and custom-built tools on a local HPC cluster and cloud-based environment.
- Perform association testing of common and rare variants in whole exome and whole genome sequencing data from cohorts of early and late-onset glaucoma and controls, and from Biobank studies as well as longitudinal cohort studies
- Build polygenic risk scores in large genotype-phenotype studies of glaucoma and test for association with various clinical features to help translate genetic discoveries into personalized approaches for disease diagnosis and treatment.
- Organize all scripts in a publicly available repository (e.g., github) with clear documentation.
- Critically review, analyze, and communicate results to our team and collaborators.
- Candidate will work both on independent and collaborative projects, and will summarize work for publications.
Qualifications
EDUCATION AND EXPERIENCE: - M.Sc. or Ph.D. in bioinformatics, computational biology, computer science, (bio)statistics, mathematics, or a related quantitative discipline required.
- Strong programming skills and in-depth experience with several programming languages required, e.g. Python, R, C ; Experience with Cloud Computing a plus.
- Experience with Unix/Linux environments, including shell scripting, is required.
- Research experience with large-scale data analysis, such as next-generation sequencing, algorithm development and statistics required.
- Background in statistical genetics, computational genomics, or machine learning is a plus.
- Motivation to contribute to genomic research of eye disease is essential.
- Demonstrate critical thinking, rigorous work, and ability to meet deadlines.
- Strong personal skills, and excellent organization and verbal and written communication skills.
- Ability to work effectively both independently and collaboratively in a fast-paced, academic environment and evolving field.
WORKING CONDITIONS: The Zebardast and Rossin labs are located in the main hospital building of Mass Eye and Ear, 243 Charles Street, in a research and office workspace that is part of MEE's Ocular Genomics Institute. The bioinformaticist will work in an office space adjacent to other computational biologists, biostatisticians, and students and in the Bioinformatics Center of the Ocular Genomics Institute, and will be part of a larger multidisciplinary research environment, which includes geneticists, clinical scientists, and experimental biologists. There is convenient access to MEE cafeteria on the 7th floor and, more importantly, abundant opportunities to interact with other MEE research groups and the Medical and Population Genetics community at the Broad Institute. This position will be hybrid with both remote and in-person components.
PHYSICAL REQUIREMENTS: None.
EEO Statement Massachusetts Eye and Ear is proud to be an equal-opportunity employer and is committed to providing a workplace free from harassment or discrimination. All employment decisions are made without regard to race, color, age, gender, gender identification, sexual orientation, religion, marital status, sex, pregnancy or conditions related to pregnancy, national origin/ancestry, citizenship, disability, military status, genetic information, or any other basis prohibited by law. These protections extend to all management practices and decisions, including recruitment and hiring practices, appraisal systems, promotions, training, and career development programs.
Primary Location
: MA-Boston-MEI Mass Eye and Ear Main Building Boston
Work Locations
: MEI Mass Eye and Ear Main Building Boston
243 Charles Street
Boston 02114
Job
: Data/Analytics
Organization
: Mass. Eye and Ear (MEE)
Schedule
: Full-time
Standard Hours : 40
Shift
: Day Job
Employee Status
: Regular
Recruiting Department : MEI Ophthalmology Research
Job Posting
: May 15, 2024
Innovation happens here and improves the lives of patients. Mass General Brigham is a not-for-profit, integrated health care system based in Boston, Massachusetts. Founded by Brigham and Women s Hospital and Massachusetts General Hospital two of the nation s leading academic medical centers. From routine care to the most complex cases, we offer comprehensive, full-circle clinical care to our patients, starting and ending at home. At Mass General Brigham, our patients come first. We offer the full spectrum of health care services for common to complex conditions, including primary care, specialty care, hospital care, virtual care, home care and more. Our approximately 74,000 employees, physicians, scientists, and health care providers, across 16 institutions, partner with patients to develop care plans tailored to their needs. We are committed to ensuring all patients have equitable access to care. Mass General Brigham doctors who drive cutting-edge research are the ones providing patient care. Our patients have access to clinical trials and advanced care that s not available elsewhere.
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Mass Eye and Ear Mass Eye and Ear, founded in 1824, is an international center for treatment and research and a teaching hospital of Harvard Medical School. Specializing in ophthalmology (eye care) and otolaryngology head and neck surgery (ear, nose and throat care), Mass Eye and Ear clinicians provide care, ranging from the routine to the very complex.
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